The Mississippi Sickle Cell Foundation (MSCF) was founded in 1996 by interested parents, patients, doctors, nurses, and other community members to raise awareness about sickle cell disease (SCD) in their community. Known as the Central MS Sickle Cell Foundation, the foundation changed its name in 2007 to the Mississippi Sickle Cell Foundation to extend its services to the entire state of Mississippi. 

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The mission of the Mississippi Sickle Cell Foundation is to enhance the quality of life for individuals living with sickle cell disease through the support of research, public activities and awareness, and patient/family education.  To accomplish its mission, MSCF sponsors educational seminars and workshops, supports group meetings, participates in health fairs across the state, supports healthcare providers, and coordinates activities that benefit patients and families throughout the state. The MSCF also holds a free annual camp for children ages 6-14, sponsors a free teen retreat for high school juniors and seniors, and aids families in need of social services. 

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The MSCF is a 501c (3) community-based organization that operates on tax-deductible donations. The Foundation is led by a Board of Directors that is governed by established bylaws. The Board is led by Jeanne Julious Tate, Chairwoman, who is a sickle cell patient and advocate. She has been a part of the foundation for over 20 years. Board members are comprised of patients, parents, nurses, doctors, and other interested supports.